Key facts
- Brand
- Agilent
- Model
- 6210 Series
- Documents
- 2
- Languages
- EN
- Last added
- 2012-07-02
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Agilent 6210 TOF MS Application Note for High Throughput LC/MS Analysis of Drug Degradation Products
This document details a high-throughput method for detecting and identifying impurities in pharmaceutical formulations, specifically analyzing more than 1000 samples per day. The methodology utilizes an Agilent 1200 Series Rapid Resolution LC system coupled with an Agilent 6210 Time-of-Flight mass spectrometer.
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How to use the product for one specific task, with worked examples.
Questions answered in these manuals
What is the maximum number of samples this system can analyze per day?
The high-throughput LC/MS TOF system is capable of analyzing more than 1000 samples per day.
From: Agilent 6210 TOF MS Application Note for High Throughput LC/MS Analysis of Drug Degradation Products
What flow rate was used for the gradient and column regeneration steps?
The method utilized a flow rate of 1 mL/min for both the gradient runs and the column regeneration process.
From: Agilent 6210 TOF MS Application Note for High Throughput LC/MS Analysis of Drug Degradation Products
What is the incubation temperature and duration for the buspirone metabolic stability study?
The reaction was carried out at 37 °C for 380 minutes.
From: Agilent 6210 Series TOF Application Note: Metabolic Stability of Buspirone
What is the flow rate used in the fast LC method?
The flow rate for the fast LC method is set to 1 mL/min.
From: Agilent 6210 Series TOF Application Note: Metabolic Stability of Buspirone