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Agilent Technologies G1600 Capillary Electrophoresis Application Note for Heparin Impurities
This document details an optimized capillary electrophoresis (CE) method for determining impurities in heparin samples, specifically oversulfated chondroitin sulfate (OSCS). The method was developed to improve upon the original USP emergency method by increasing resolution and sensitivity. It utilizes a 25 µm inner diameter bubble cell capillary with highly concentrated lithium phosphate buffers at low pH.
Read onlineAgilent G1600 specifications
| Capillary length to DAD | 21.5 cm |
|---|---|
| Capillary length to LC/MSD Trap | 84.0 cm |
| Diode array wavelength | 375 nm, bandwidth 75 nm |
Source: Agilent G1600A/LC-MSD Trap XCT Toxicology Drug Screening Application Note
All Agilent G1600 documents by type
How to use the product for one specific task, with worked examples.
Mounting, wiring and first power-up. Read it before the hardware goes in.
Questions answered in these manuals
What is the limit of detection for OSCS using this optimized method?
The limit of detection for OSCS is well below 0.1%.
From: Agilent Technologies G1600 Capillary Electrophoresis Application Note for Heparin Impurities
What is the optimal buffer concentration for separating heparin impurities?
The optimal buffer used in this method is 600 mM lithium phosphate at pH 2.5.
From: Agilent Technologies G1600 Capillary Electrophoresis Application Note for Heparin Impurities
What is the detection limit for drugs in whole blood using this system?
The system can detect drugs at concentrations less than 20 ng/mL in whole blood.
From: Agilent G1600A/LC-MSD Trap XCT Toxicology Drug Screening Application Note
Can the Agilent CE-MS system identify drugs during a single run?
Yes, generating MS" data permits reliable identification of detected drugs, allowing both screening and identification in one or two injections.
From: Agilent G1600A/LC-MSD Trap XCT Toxicology Drug Screening Application Note
What is the part number for the new tray belt?
The new tray belt has part number 1500-1040.
From: Agilent G1600-60026 Tray Belt Modification Installation Guide
Does the modification kit include a roller plate?
Yes, the instructions specify putting the roller plate on top of the foam.
From: Agilent G1600-60026 Tray Belt Modification Installation Guide