The document describes a drug called Verapamil, which is a calcium antagonist used to treat hypertension, cardiac arrhythmia, and angina pectoris. The drug also shows some prophylactic effects against migraines.
The document details a High-Performance Liquid Chromatography (HPLC) method for analyzing the antianginal drug verapamil. The procedure utilizes reversed-phase chromatography on a Zorbax SB-C18 column, employing a mobile phase of potassium dihydrogen phosphate and acetonitrile with a gradient elution profile.
The autosampler temperature was set to 4°C to avoid decomposition of samples.
The recommended guard cartridges have a size of 5 µm, 4.6 x 12.5 mm.
The analysis uses an excitation wavelength of 228 nm and an emission wavelength of 312 nm.