This article compares the detection techniques UV, fluorescence, and mass spectrometry in combination with standard and capillary LC systems and columns with different internal diameters. The advantages and disadvantages of the different detector/column/LC system combinations are discussed.
This document evaluates the performance of different detection methods—UV, fluorescence, and mass spectrometry (MS)—when combined with standard and capillary Liquid Chromatography (LC) systems from the Agilent 1100 Series. The study focuses on determining the limit of detection for four specific beta-blocking drugs: Pindolol, Timolol, Metoprolol, and Propranolol.
The analysis included Pindolol, Timolol, Metoprolol, and Propranolol.
The limit of detection for Propranolol using fluorescence detection is about 120 pg.