Agilent Manuals - Page 157

Agilent manuals, page 157

• Agilent Excellent Reproducibility Using Temperature Gradient Chromatography with the Agilent 1200 Series Rapid Resolution Liquid Chromatography System

  Using an Agilent 1200 Series LC system, featuring the G1316B Thermostatted Column Compartment, is used to generate reproducible chromatography with a programmable tem- perature gradient

• Agilent Technologies Analysis of beta-blocking drugs in biological fluids using on-line off-line sample preparation methods Agilent 1100 Series LC systems

  This application note describes the use of the Agilent 1100 Series LC system for the analysis of β-blockers in blood and other biological fluids using online and offline sample preparation methods.

• Agilent Technologies Continuous Operation of a High Throughput LC/MS System in a Walk-Up Environment

  The Agilent 1200 Series Rapid Resolution LC system can operate continuously to meet the stringent requirements of multiple medicinal chemists for a high-throughput LC/MS system.

• Agilent Technologies High throughput HPLC - Alternating column regeneration with the Agilent 1100 Series valve solutions

  Using two identical columns and a second pump can achieve high-throughput analytical HPLC.

• Agilent Technologies Optimizing the Agilent 1100 series well-plate sampler

  Optimizing the Agilent 1100 Series well-plate sampler

• Agilent Technologies Label-free analysis of microsatellite instability in colorectal carcinoma by on-chip electrophoresis

  Microfluidic chips for detecting microsatellite instability

• Agilent Technologies Fast identification of main drug metabolites by quadruple time-of-flight LC/MS

  This Application Note presents a workflow for the identification of main drug metabolites by sample comparison as well as by structure elucidation of the identified metabolites based on accurate MS and MS/MS data acquired with a quadrupole time-of-flight (Q-TOF) LC/MS. In pharmaceutical drug development the main metabolites of a new drug candidate must be identified as fast as possible and with high confidence. Software for this task is described, which analyzes the metabolized drug samples and visualizes the differences with non- metabolized drug samples for manual investigation. The structures of possible metabolites are elucidated by examination of the original highly-accurate Q-TOF mass data based on the differences between the metabolized and non-metabolized drug samples.

• Agilent Technologies Genome-wide Monitoring of CpG Island Methylation With Agilent\

  This application note describes how to use Agilent’s Tiling Microarray Technology to monitor genome-wide methylation patterns in CpG islands.

• Agilent Technologies Fast high-resolution analysis of notoginseng by rapid resolution liquid chromatography

  This document describes the development of a rapid resolution liquid chromatography (RRLC) method for the analysis of notoginseng. The method has good resolution and can be used to quickly analyze complex components, thereby increasing sample throughput and lowering costs. The method can also be used to analyze compounds in different parts of the notoginseng plant, and different peak profiles and different concentrations of certain saponins are detected.

• Agilent Technologies Comparison of ZORBAX StableBond 300 Å LC Columns to Optimize Selectivity for Antibody Separations Using HPLC LC/MS

  This article describes the optimization of selectivity for antibody separations using HPLC and LC/MS by increasing the percentage of n-propanol and acetonitrile in 0.1% trifluoroacetic acid using ZORBAX 300 Å SB-CN LC Columns.

• Agilent Technologies Improved Metabolite Isolation from Samples of Biological Origin Using Liquid

  This article introduces the techniques for isolating metabolites from biological samples using liquid chromatography with sub-2-micron particle columns. The method improves the rate and resolution of metabolite separation without compromising the overall purity or recovery of the metabolites.

• Agilent Technologies Rapid selective quantification of drug compounds for cassette-dosing DMPK studies by multi-MRM triple quadrupole MS

  This Application Note describes: • The rapid development of an MRM triple quadrupole MS method for compound quantification. • The fast liquid chromatography separation on 1.8 µm RRHT columns for high throughput of DMPK samples. • The application of the developed LC/MS MRM method for the quantification of compounds in a mixture by a multi MRM method.

• Agilent MassHunter Metabolite Identification Software Application Note

  Application Note 8 pages · 756 KB · EN

  This application note describes an interwoven, multi-algorithm approach for computer-assisted identification of drug metabolites using Agilent MassHunter…

• Agilent 6410 Triple Quadrupole LC/MS Application Note: Metabolic Stability Determination

  Application Note 8 pages · 1.1 MB · EN

  This application note describes the rapid development of an MRM method using Agilent 1200 Series RRLC and 6410 triple quadrupole LC/MS for determining…

• Agilent 6410 MS Application Note: Determination of Cocaine and Metabolites in Hair

  Application Note 8 pages · 387 KB · EN

  This application note describes a validated LC/MS/MS method for quantifying cocaine, benzoylecgonine, cocaethylene, and norcocaine in human hair using an…

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