The Agilent 1200 Series Rapid Resolution LC system can operate continuously to meet the stringent requirements of multiple medicinal chemists for a high-throughput LC/MS system.
This document details a high-throughput LC/MS system configuration designed for walk-up environments in drug discovery. The setup utilizes an Agilent 1200 Series Rapid Resolution LC system paired with an Agilent 6140 Quadrupole LC/MS. Key components include a standard autosampler SL with an external tray for unlimited sample capacity and Easy Access software for automated sample management.
| Autosampler capacity | 17 positions for samples |
|---|---|
| Column particle size | 1.8 um |
| DAD sampling rate | up to 80 Hz |
| MS scan speed | up to 10,000 u/sec |
| Column dimensions | 3x 50mm |
| Column temperature | 80 °C |
The Easy Access software is used to direct the sampler arm and manage the sample queue.
Continuous operation is achieved by using an external tray on the autosampler that allows for effectively unlimited sample capacity.
The MS operates in combined ESI-APCI mode with a scan range of m/z 100 — 600.