The Varian 500-MS Ion Trap Mass Spectrometer can be used for the analysis of isocyanate derivatives. This method separates and identifies four isocyanate derivatives at low concentrations, with a short analysis time.
Isocyanate compounds are widely used in the manufacture of pharmaceuticals, pesticides, and polyurethanes but pose high toxicity risks. This document presents a Liquid Chromatography-Mass Spectrometry (LC/MS) method designed to separate and identify four specific isocyanate derivatives at low or sub-ppb levels.
The method is completed in less than five minutes.
The lowest limit of detection is 75 ppt for HDI.
The highest limit of detection is 375 ppt for HDI-IC.