Industrial

This Application Note describes a method of injecting large sample volumes using an Agilent 1100 Series purification system and injection pump.

This application note demonstrates the configuration of the Agilent 1200 Series RRLC AS purification system and the use of an optimized method for purifying dye-labeled or Fmoc-protected peptide nucleic acids from solid-phase synthesis. It provides an overview of the characteristics and applications of peptide nucleic acids.

This document describes the application of the Agilent 1100 Series 12-position/13-port valve in compound isolation and purification in the pharmaceutical industry. The system is optimized for high throughput, capacity, and productivity. This application note demonstrates how the Agilent 1100 Series valve can enhance the purification system by adding easy recovery collection and simple time-based fraction collection.

To increase throughput in preparative HPLC, it is necessary to load high amounts of sample onto the column. This application note describes two common techniques - sandwich injection and organic-phase injection, and how they can be performed easily on an Agilent 1100 Series purification system.

The UC385 is a low dropout linear regulator that responds quickly to fast load changes. It has a precision onboard reference and excels at driving GTL and BTL buses. Due to its fast response to load transients, the total capacitance required to decouple the regulator's output can be significantly decreased compared to standard LDO linear regulators. The dropout voltage (VIN to VOUT) is only 490mV maximum and 350mV typical at a 5A load (0°C to 100°C). The onboard bandgap reference is stable with temperature and scaled for a 1.2V input to the internal power amplifier. The UC385 is available in fixed output voltages of 1.5V, 2.1V, or 2.5V. The output voltage of the adjustable version can be set with two external resistors. If the external resistors are omitted, the output voltage defaults to 1.2V.

This Application Note describes a more sophisticated approach to peak-based fraction collection by using the parameters up and down slope, upper threshold and maximum peak duration.

This article discusses the importance of impurity isolation and purification in impurity profiling using the Agilent 1200 Series LC system, and elucidates the structures of impurities through NMR analysis. By optimizing the method and conducting loading experiments, the impurities were successfully isolated from the crude sample with high purity and recovery. Sufficient amounts of each compound were obtained through repetitive injections for further structural elucidation.

This Application Note describes a method for generating a small method set based on retention time windows in the pre-preparative analytical run. Using Agilent standards with known elution properties makes this an easy four-step process, which can be accomplished in less than one hour. An application example demonstrating how the resolution of the target compound can be improved is also shown.

This Application Note describes the isolation of three antianginal drugs (nifedipine, nisoldipine, and nimodipine) from a mixture as an example application for purification of pharmaceutical drugs using the Agilent 1100 Series purification1,2 system PS (preparative scale). The goal of the application was to purify 20 mg of each compound in a single run and to get three fractions containing only the desired substances.

This document is provided by ICminer.com Electronic-Library Service. The service is copyrighted in 2003. The document describes the features and characteristics of ICminer.com Electronic-Library Service.

The TS393C,I,M are STMicroelectronics' micropower CMOS dual voltage comparators with extremely low consumption (9µA typ / comparator) and extremely low input offset currents (1pA typ). This comparator works in the temperature range of -55°C to +125°C and has similar performance with the dual micropower comparator TS3702.

The Littelfuse TMOV and iTMOV varistors are integrated circuit protection devices that provide quick thermal response and low inductance. They are designed to protect against overheating caused by abnormal over-voltage and limited current conditions. The iTMOV varistor includes a third lead for indicating disconnection from the circuit. These varistors are wave solderable, simplifying product assembly. They are recognized surge suppression components to UL 1449.