This document describes the application of the Agilent 1100 Series 12-position/13-port valve in compound isolation and purification in the pharmaceutical industry. The system is optimized for high throughput, capacity, and productivity. This application note demonstrates how the Agilent 1100 Series valve can enhance the purification system by adding easy recovery collection and simple time-based fraction collection.
This document describes how to enhance an Agilent 1100 Series purification system using the 12-position/13-port valve. It details two specific applications: recovery collection, where uncollected samples are diverted to a dedicated container to prevent loss, and time-based fraction collection, which allows for simple purification without a dedicated fraction collector.
The text provides setup instructions for the valve within the Agilent ChemStation and Purification/HighThroughput software. It explains how to configure the valve for recovery collection to handle up to twelve samples and how to set up time-based fraction collection using a timetable, ensuring mobile phase is directed to waste during non-analysis periods.
Time-based fraction collection works only with the ChemStation software; the Purification/HighThroughput software is neither required nor supported.
With the 12-position/13-port valve, the recovery of up to twelve samples can be collected.
This setting automatically switches the valve to the next recovery location after a run is finished and keeps that position for the next run.