Agilent manuals, page 151
Agilent Technologies HPLC Preparative Scaleup of Calcium Channel Blocker Pharmaceuticals Application Note
Agilent Reversed Phase Prep columns demonstrated both good loadability and good scalability for calcium channel blockers using gradient conditions. The columns also dis- played good resolution at all dimensions and allowed a linear scaleup from analytical to preparative dimensions
Agilent Technologies Using DMSO as an Injection Solvent to Increase Sample Load in Preparative LC Application Note
This article describes a method for increasing sample load in preparative liquid chromatography by using DMSO as the injection solvent.
Agilent Technologies Preparative Purification of Corticosteroids by HPLC; Scalability Loadability Using Agilent Prep C18 HPLC Columns Application Note
This paper mainly introduces the method of using Agilent Prep reverse phase column to realize the gradient separation of corticosteroids. Different diameter Agilent Prep reverse phase columns show nearly linear scale-up for the gradient separation of corticosteroids. With as much as 8 mg of total corticosteroid injected onto a 4.6 mm column and 320 mg onto a 30 mm column, the loadability of the columns is quite good.
Agilent Technologies Time-of-Flight Solutions in Pharmaceutical Development - the Power of Accurate Mass Application Note
This compendium describes the applications of the Agilent LC/MSD TOF technology in the pharmaceutical industry, focusing on the advantages of high resolution, high accuracy, and wide dynamic range TOF mass spectrometry in drug development.
Agilent Technologies Quality Control for the Agilent 2100 Bioanalyzer Protein 200 Plus LabChip Kits service manual
This technical note describes some of the typical quality control tests and specifications for Agilent 2100 Bioanalyzer Protein 200 Plus LabChip Kits.
Agilent Technologies Cell fluorescence assays on the Agilent 2100 bioanalyzer Application Note
This Application Note describes the general use of cell fluorescence assays on the Agilent 2100 bioanalyzer. The cell assay extension together with the cell fluorescence LabChip® kit allows both the analysis of pre-stained cells and the analysis of cells by on-chip staining. Cell assays on the 2100 bioanalyzer are based on simple flow cytometric analysis. The technical principles, as well as the typical workflow in sample and chip preparation are described here. A typical dye optimization experiment was performed and the appropriate dye concentration for a specific cell line determined. The cell fluorescence software is easy-to-use and allows different forms of data evaluation and result presentation. Using an example, data evaluation is explained in detail. Specific advantages of cell fluorescence analysis with the Agilent 2100 bioanalyzer are low cell and reagent consumption, ease-of-use, automated data acquisition and evaluation of up to six samples.
Agilent Technologies The Total RNA Story Manual
This application is a tool to aid RNA data interpretation and identify features from total RNA electropherograms that reveal information about RNA sample quality.
Agilent Technologies Hydrophilic Interaction Chromatography (HILIC) Separation of Basic Drugs using MS/MS Detection Application Note
This paper introduces a method for the separation of basic drugs, such as ranitidine and paroxetine, based on hydrophilic interaction liquid chromatography (HILIC) and electrospray ionization mass spectrometry (MS/MS) detection. The method showed good linearity over the 0.5–100 ppb levels. A spiked serum was cleaned up by protein precipitation and an aliquot was directly injected into the HILIC/ESI-MS system. Recovery was found to be 98% for ranitidine and 79% for paroxetine at the 100 ppb level.
Agilent Technologies Determination of EU-Banned Disperse Dyes by LC/MSD TOF Application Note
Agilent Technologies Smooth Secure Integration of Cerity Pharmaceutical QA/QC with LIMS systems using Labtronics LimsLinkCDS Application Note
Laboratories can improve the efficiency of their operations and ensure the accuracy of their data reporting, by automating the transfer of information between their chromatography data system (CDS) and their laboratory information management system (LIMS). In addition, the security of their chromatography data is enhanced when this automation is accomplished within the security framework established by regulatory guidelines such as the U.S. Food and Drug Administration’s ruling on electronic signatures and electronic records (21 CFR Part 11). This case study describes how Labtronics LimsLinkCDS enables laboratories to, smoothly and securely, integrate Agilent Cerity for Pharmaceutical QA/QC with any LIMS.
Agilent Technologies Automated method development using Agilent 1100 Series HPLC systems Agilent ChemStation ChromSword software Application Note
This is an article about the automated method development of Agilent 1100 Series HPLC systems. The article introduces the use of ChromSword Auto software in Agilent 1100 Series HPLC systems and Agilent ChemStation software.
Agilent Technologies Automated method development using Agilent 1100 Series HPLC systems Agilent ChemStation ILS ChromSmart MD software Application Note
This document introduces the automatic method development of Agilent 1100 Series HPLC systems, Agilent ChemStation software and ILS ChromSmart MD software.
Agilent Networking Possibilities in the Analytical Laboratory with Agilent Instrumentation Data Systems
This application note describes the possibilities of networking computers in an analytical laboratory using Agilent instrumentation and data systems. The benefits of networking are introduced, as well as how to use the IEEE 802.11b standard to achieve wireless network connectivity.
Agilent Levels of instrument control with chromatography data systems the implications for compliance
This document describes the different levels of instrument control with chromatography data systems and their implications for compliance. It provides a checklist for evaluating the capability of instrument control and data handling software.
Agilent Retention Time Locking: Creating Custom Retention Time Locked Screener Libraries
This document provides a general method for using finite element analysis in engineering modeling tools and system simulation tools. The goal of this method is to provide a structured method for creating finite element models and integrating them into larger engineering modeling and system simulation systems.