This is an article about the automated method development of Agilent 1100 Series HPLC systems. The article introduces the use of ChromSword Auto software in Agilent 1100 Series HPLC systems and Agilent ChemStation software.
The document describes how to automate the repetitive process of developing High-Performance Liquid Chromatography (HPLC) methods using the ChromSword software package. It details the capabilities of ChromSword in optimizing separations for reversed-phase, normal-phase, and ion-exchange chromatography, either offline or online with Agilent 1100 Series systems.
The guide provides step-by-step instructions on configuring the ChromSword software using the HPLCAdmin program to connect it with ChemStation. It outlines procedures for setting up experiments, including entering compound data, drawing molecular structures, and running automatic optimization wizards to generate separation conditions.
ChromSword can be used for optimizing separations in reversed-phase, normal-phase and ion-exchange liquid chromatography.
The Agilent ChemStation software must be revision A.09.01 or higher.
It supports binary pump, quaternary pump, standard autosampler, column compartment including the built-in column selection valve, variable wavelength detector, multi-wavelength detector and diode array detector.