This Application Note describes the basic principles and conditions of using Agilent ZORBAX StableBond columns to separate ulcer drugs.
This document is an application note detailing the analysis of ulcer medications, specifically Cimetidine, Famotidine, and Pirenzepine. It explains that these drugs work as histamine H2-receptor antagonists to treat ulcers by inhibiting stomach acid production. The text notes that ulcer medications are the second most frequently prescribed drugs after cardiac drugs.
| Column | ZORBAX SB-CN (4.6 x 150 mm; 3.5um) |
|---|---|
| Mobile Phase | 90% 25 mM NaH2PO4 Monobasic (pH 3.0) : 10% Acetonitrile |
| Flow Rate | 1 mL/min |
| Temperature | 35°C |
| Detection | UV (220 nm) |
This application was developed for general interest regarding the analysis of ulcer medications.
The column temperature is set to 35°C.
The flow rate is set to 1 mL/min.