This application note introduces the superior mass accuracy of the Agilent 6540 Accurate-Mass Q-TOF for high-confidence characterization of unknowns. The capability of the instrument was tested by analyzing a sample described as a compound with a nominal molecular weight of 218 and determining its correct molecular formula.
The document introduces the Agilent 6540 Accurate-Mass Q-TOF LC/MS System, highlighting its ability to provide outstanding mass accuracy and isotopic fidelity. This performance helps reduce the number of candidate molecular formulas for unknown samples by eliminating incorrect options through high-quality data.
The mass error was only 0.33 ppm.
The MS/MS mass accuracy is better than 2 ppm.
It provides accurate mass measurements regardless of spectral acquisition rate.