High-Throughput LC/MS/MS for cytostatic drugs with an Agilent 1290 Infinity LC System coupled to a tandem mass spectrometer
This document presents an application note comparing the performance of the Agilent 1290 Infinity LC system against the older Agilent 1100 Series LC system when used with a tandem mass spectrometer for detecting cytostatic drugs. The study highlights improvements in speed, resolution, and sensitivity achieved by the newer system.
The system has a pressure stability of up to 1200 bar.
Using the 1290 Infinity LC system with a 2 mm id column reduces organic solvent consumption by 62 %.
The minimum dwell time of the API 3000 mass spectrometer is 50 ms.