This application note describes a method for determining the N-nitrosamine content in rubber articles using the Agilent 7000A triple quadrupole GC/MS system. The method employs an internal standard, N-nitroso-N-dipropylamine (NDPA), for the trace-level detection and confirmation of seven target N-amines, N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosodibutylamine (NDBA), N-nitrosopiperidine (NPIP), N-nitrosopyrrolidine (NPYR), N-nitrosomorpholine (NMOR), and N-nitroso-N-ethyl-N-phenylamine (NEPhA). The resulting low method detection limit, good linearity, and sample recovery demonstrate the high selectivity and sensitivity of the method described in this application note for trace-level detection and confirmation of the targeted N-amines in complex sample matrices.
This document presents an analytical method for detecting seven common N-nitrosamine compounds (NDMA, NDEA, NDBA, NPIP, NPYR, NMOR, and NEPhA) in rubber articles. The method utilizes an Agilent 7000A Triple Quadrupole GC/MS system combined with an Agilent J&W DB-624 column to achieve trace-level detection and confirmation in complex sample matrices.
| Detection mode | MRM Mode |
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The method analyzes seven compounds: NDMA, NDEA, NDBA, NPIP, NPYR, NMOR, and NEPhA.
The European Union imposed a maximum concentration of 10 ppb (g/kg) for total N-nitrosamines.
The US FDA established a maximum level of 10 pg/kg for individual N-nitrosamines.
The method detection limit for N-nitrosodimethylamine is 1.05 ng/kg.