This study focuses on the rapid screening of an entire hippocampus section of mouse brain for the study of Alzheimer’s disease. The aim was to investigate whether there was a correlation between the tissue’s chemical composition and protein secondary structure with tissue morphology, in order to provide insight into the disease process. Agilent’s 670 and 620 FTIR imaging analysis, combined with a chemical imaging microscope and FTIR spectrometer, were used for this research.
This document details an application using Agilent's 670 FTIR spectrometer and 620 FTIR spectrochemical microscope to study Alzheimer's disease. The study focused on the rapid screening of a mouse hippocampus section to investigate the correlation between tissue chemical composition and protein secondary structure.
| Spectral resolution | 4 cm-1 |
|---|---|
| Spatial resolution | 5.5 micron |
| Detector type | 64 x 64 focal plane array |
| Scans | 128 |
| Mosaic configuration | 4x6 |
Agilent's Resolutions Pro software.
The measurements were performed at a spatial resolution of 5.5 microns.
The data was collected in about 30 minutes.