This application note provides detector linearity testing results for Aripiprazole quality control using the Agilent 1120 Compact LC system and ZORBAX C-18 columns. The study results show that the system has excellent linearity, peak area precision, and retention time precision.
This document presents an application note evaluating the performance of the Agilent 1120 Compact LC system. The study focuses on the linearity and precision of peak areas and retention times when analyzing the antipsychotic drug Aripiprazole. The evaluation utilizes a ZORBAX Eclipse XDB-C18 column and a variable wavelength detector (vWD) set to 254 nm.
| Flow rate | 1.0 mL/min |
|---|---|
| Column oven temperature | 40 °C |
| Detector wavelength | 254 nm |
| Linearity correlation | > 0.9999 |
The study covers a wide range of approximately 150 ng to 5,000 ng.
The RSD for retention times was less than 0.07% for all six linearity levels.
The RSD for peak areas was less than 0.25% for all six levels.