Agilent Manuals

This document demonstrates the femtogram sensitivity of the antipsychotic drugs Raclopride and Ritanserin using the Varian 1200L LC/MS/MS in selected reaction monitoring mode (SRM). Ritanserin is a serotonin-2 antagonist drug shown to be effective in the treatment of anxiety and depression, while Raclopride acts as a dopamine D2 receptor antagonist. The document also provides information on the instrumentation and sample preparation methods used in the study.

This document presents a detailed hydrocarbon analysis of petroleum naphthas using the ASTM D 5134 method. The method utilizes Varian's GC instrumentation and CP-Sil PONA CB™ column to determine hydrocarbon components eluting after n-nonane. This method is important for quality control, controlling refinery processes, and evaluating raw materials.

This application note describes work to determine if concurrent heating could be used to significantly reduce the analysis time and improve sample throughput in the PIONA+ mode.

This article describes the application of Varian's 320-MS triple quadrupole LC/MS/MS system in the direct aqueous injection and automated on-line solid phase extraction (SPE) analysis of phenoxy herbicides in drinking water. Phenoxy herbicides are a class of chemicals related to the growth hormone indoleacetic acid. Contact with broad-leaf plants induces rapid, uncontrolled growth, killing the affected plants. Phenoxy herbicides are widely used to selectively destroy broad-leaved weeds amongst wheat or corn crops. The best-known phenoxy herbicides are 2,4-dichlorophenoxy-acetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). 2,4,5-T itself is only moderately toxic, with an oral LD50 of 389 mg/kg. However, the manufacturing process for 2,4,5-T contaminates this chemical with trace amounts of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is reported to be extremely toxic to humans. 2,4-D has not been reported as being contaminated with TCDD, however it is one of the most widely used herbicides in the world and is a regulated drinking water contaminant in the United States and other countries.

This application note describes how to use the SelecTemp™ and SelecFlow™ features on the Varian 325-MS triple quadrupole mass spectrometer to determine pesticides in a QuEChERS matrix.

This application note examines some analytical figures of merit for selected elements in a variety of lamp combinations using flame atomic absorption spectrometry. The same elements are determined in a number of steel reference materials and samples, with similar results. Evidence is presented that well-designed multi-element lamps can give analytical performance at least as good as that of single-element lamps.

This application note describes the analysis of very low levels (sub ppm) of 1,2-dichloroethane in which a special sample concentratior was used in conjunction with the Varian CP-4900 DMD Micro-GC with differential mobility detector.

This document describes a method for analyzing vulcanized rubber formulations using the Varian 500-MS ion trap mass spectrometer and confirming expected structures using Varian TurboDDS™ and ACD/MS Manager software.

Analysis of Chloramphenicol in Shrimp by LC/MS/MS

This application note demonstrates how phospholipids can be identified in a mixture by triple quadrupole mass spectrometry and suspected structures confirmed by generating MS/MS spectra and submitting it to the ACD Labs/MS Manager software.

This document describes the analysis method for sulfur components in various LPGs. A highly selective pulsed flame photometric detector is used, and a dual-channel configuration is employed for the analysis. This method allows for the analysis of all components of interest in one run.

This article describes a method for quantitative measurement of the cardiac glycoside, Digoxin, in human plasma using a Varian 1200L LC/MS/MS system in the negative ion detection mode. This method is capable of detecting Digoxin levels as low as 15 picograms.

This application note introduces a new method for studying the dynamics of biomolecules, based on ultrafast NMR spectroscopy and the performance of Varian cold probes.

This is an application note that introduces the application of mass spectrometry with evaporative light scattering detection