Agilent Manuals

This application note describes an analytical method for the determination of herbicides in drinking water using the Agilent 1120 Compact LC. The method is characterized by high retention time and peak area precision and low detection limits.

This Application Note describes the development and validation of a method for simultaneous determination of paracetamol, diclofenac and ibuprofen using the Agilent 1120 Compact LC. The method has excellent precision, accuracy and low limits of detection.

This Application Note describes the analysis of several well known preservatives like benzoic acid, sorbic acid or the esters p-hydroxy benzoic acid (methyl-, ethyl- and propyl-) with the Agilent 1120 Compact LC. It demonstrates the relevance of this method for quality control testing and monitoring of products for consumer protection.

This Application Note describes the analysis of several degradation products of metoprolol with the Agilent 1120 Compact LC. The preceding method development was done with the Agilent 1200 Series Rapid Resolution LC (RRLC) system. This Application Note starts with the final result of method development, to prove that no further development is necessary. It shows that the Agilent 1120 Compact LC works as a reliable and highly robust instrument for standard LC methodology. The transfer from rapid resolution separation material to conventional columns by the Method Translator Software is shown. The results of system suitability and performance tests prove the reliability and quality of the Agilent 1120 Compact LC system for everyday quality control testing.

This Application Note compares the results of the development of an accurate and reproducible method to analyze paracetamol and related impurities according to European Pharmacopoeia (EP) and USP regulations1, using an Agilent 1120 Compact LC and a 1200 Series LC system.

This application note describes a method for analyzing three of the most popular artificial sweeteners in foods and beverages using the Agilent 1120 Compact LC system. The system suitability results showed that the Agilent 1120 Compact LC is the system of choice for conventional, analytical scale liquid chromatography. This integrated HPLC system was designed for ease of use, performance, and reliability. The quantitative analysis of typical samples is demonstrated in this Application Note.

This application note describes three methods for the determination of melamine in dairy products: an improved version of the U.S. FDA method, a high-throughput method using an Agilent Rapid Resolution LC (RRLC) system, and an alternative ion-exchange LC method. Due to the complexity of dairy product matrices, a cleanup step using solid phase extraction (SPE) is required for the above methods. The Agilent SampliQ SCX, a mixed-mode polymer SPE cartridge with combined reversed-phase and strong cation exchange properties, is used to successfully remove matrix interferences.

This application note provides detector linearity testing results for Aripiprazole quality control using the Agilent 1120 Compact LC system and ZORBAX C-18 columns. The study results show that the system has excellent linearity, peak area precision, and retention time precision.

The Agilent 1120 Compact LC is the system of choice for conventional, analytical-scale liquid chromatography. It is an integrated LC designed for ease of use, performance, and reliability. It is well-suited for in-process control during drug manufacturing, due to the highly precise retention times and peak areas. This Application Note shows: Excellent retention time precision, with a relative standard deviation (RSD) < 0.07 %. Excellent area precision, with RSD < 0.25 % for baseline-separated peaks.

This Application Note describes the System Suitability Testing (SST) results of Aripiprazole quality control with the Agilent 1120 Compact LC and ZORBAX C-18 columns. The system is shown to have excellent precision in retention time, area and height measurements.

The document describes the system suitability testing for Tramadol quality control using the Agilent 1120 Compact LC and ZORBAX C-18 columns. The system demonstrates excellent retention time precision and peak area precision, making it suitable for drug analysis.

This application note describes the method for purity analysis of pravastatin sodium using the Agilent 1120 Compact LC. The method is established by the United States Pharmacopeia (USP) and validated on the Agilent 1120 Compact LC.

This Application Note demonstrates the configuration of the Agilent 1200 Series Rapid Resolution LC (RRLC) analytical scale (AS) purification system and its optimized method for purification of peptides from solid-phase synthesis.

This Application Note demonstrates the excellent linearity performance of the Agilent 1120 Compact LC autosampler. The system can be used to perform linearity calibration for samples ranging from 1 to 100 µL. The results show that the Agilent 1120 Compact LC autosampler has a linearity coefficient of R2 > 0.9999.

This article introduces a method for separating 19 amino acids using an Agilent 1200 RRLC system, including two sulfurated amino acids, and transferring it successfully to an Agilent 1100 HPLC system. Good separation of this method was achieved by using Agilent ZORBAX Eclipse Plus C18 column on both two system. The results demonstrated that this analytical method was simple, reliable for analyzing these 19 amino acids, and the method is useful in comprehensively evaluating the quality of feed, food and pharmaceutical products which containing sulfurated amino acids.