Agilent 255 Nitrogen Chemiluminescence Detectors (NCDs) can be used as an alternative to Thermal Energy Analyzers (TEAs) for nitrosamines analysis, providing higher resolution and faster runtimes.
Nitrosamines are carcinogenic compounds found in various matrices, and gas chromatography combined with selective detection is a primary technique for their analysis. A major supplier of cGMP analytical services sought an alternative to aging Thermal Energy Analyzers (TEAs) to reduce repair expenses and improve reliability.
The company replaced the TEAs with two Agilent 255 Nitrogen Chemiluminescence Detectors (NCDs). Bridging studies demonstrated that the NCDs yielded essentially equivalent results to the TEAs, but with higher resolution, faster runtimes (10 minutes vs. 27 minutes), and more stable baselines.
The run time for the Agilent 255 NCD is 10 minutes.
The CTR traps require replacement after approximately 50 analyses.