This document describes the Agilent 1260 Infinity SFC/MS solution, which provides superior sensitivity by seamlessly interfacing to the Agilent 6100 Series LC/MS system
This document describes two instrument configurations for connecting the Agilent 1260 Infinity Analytical SFC system to a mass spectrometer, utilizing either atmospheric pressure chemical ionization (APCI) or electrospray (ESI) sources. The text details experimental setups that achieve superior sensitivity and repeatability without effluent splitting.
The system achieves a retention time reproducibility of less than 0.3% RSD.
The solution provides a peak area reproducibility of less than 10% RSD.
SFC coupled with mass spectrometric detection is 10 times more sensitive than UV detection.