Agilent Salt Tolerant Cold Probe provides the highest sensitivity for lossy samples such as proteins in aqueous solutions containing high concentrations of buffer or salt
The Agilent Salt Tolerant Cold Probe provides the highest sensitivity available when working with lossy samples such as proteins in aqueous solutions containing high concentrations of buffer or salt. It achieves nearly 75% sensitivity improvements in triple resonance experiments on protein samples compared to conventional cryogenically cooled or room temperature probes.
The probe utilizes a unique sample geometry, specifically a 3 x 6 S-Tube design, to maximize absolute sensitivity by redistributing the sample into regions of low E-Field. This innovative approach minimizes interaction with areas of strong electric fields, effectively reducing losses caused by high salt concentrations ranging from 50 mM NaCl up to 1 M.
The probe is designed for samples where salt concentration ranges from 50 mM NaCl to as high as 1 M.
The probe has shown sensitivity improvements of nearly 75% in triple resonance experiments on protein samples.
Users can expect time savings of more than a factor of two compared to other probes.