This document describes that Agilent Technologies' Rx-Silica highlights good peak shape of basic compounds in opiate drugs. These basic compounds have poor peak shape on many reversed-phase columns. ZORBAX Rx-SIL has an extremely homogeneous silica surface with uniform associated silanols and low acidity. ZORBAX Rx and StableBond columns show significantly reduced band tailing and improved column efficiency when analyzing basic compounds.
The document highlights the analysis of basic compounds, specifically opiate drugs such as Morphine, Codeine, Oxymorphone, and Naloxone. These compounds are noted to typically exhibit poor peak shape on many reversed-phase columns.
Agilent ZORBAX Rx-SIL and StableBond columns are presented as a solution due to their extremely homogeneous silica surface with uniform associated silanols and low acidity. The text states that these columns show significantly reduced band tailing and improved column efficiency when analyzing basic compounds.
The column used for the analysis has dimensions of 4.6 x 150 mm.
The analysis is performed at a flow rate of 1.5 mL/min.