This document describes the analysis of drugs of abuse using GC/MS with the Ultra Inert Inlet Liners with Wool. These liners provide excellent inertness, homogeneous sample mixing and evaporation, non-volatile residue trapping, and column and detector protection for drugs of abuse screening.
This document details the use of Agilent Ultra Inert inlet liners with glass wool for the screening of drugs of abuse using Gas Chromatography-Mass Spectrometry (GC/MS). The liners are designed to provide excellent inertness, homogeneous sample mixing, and protection for the column and detector, which is critical when analyzing heavy-matrix samples like plasma or urine extracts.
The note presents experimental results evaluating the performance of these liners against 28 popular and difficult basic drug compounds. It outlines the specific instrumentation setup, including the Agilent 7890A GC system and 5975C MSD, along with detailed instrumental conditions and Selected Ion Monitoring (SIM) parameters used for the analysis.
| Inlet Splitless mode temperature | 280 °C |
|---|---|
| Purge flow | 50 mL/min |
| Inlet pressure | 18.7 psi |
| Oven initial temperature | 100 °C |
| Oven final temperature | 325 °C |
| Transfer line temp | 300 °C |
| Source temp | 300 °C |
| Scan mass range | 40-570 amu |
They provide excellent inertness to prevent adsorption or decomposition of target analytes, ensuring accurate and reproducible responses.
The testing was conducted on an Agilent 7890A GC system equipped with a 7683B autosampler and a 5975C MSD.