The document introduces an economical instrument configuration using the Agilent 7820A GC and 7697A headspace sampler for measuring ethanol in blood. It has good repeatability and easy-to-use operation, making it ideal for routine QA/QC labs. According to national standards, drunk driving is defined as a concentration of ethanol in the blood of 80 mg/100 mL or more, while drinking and driving is defined as a concentration of ethanol in the blood of 20 mg/100 mL or more. To meet this quantitative requirement, the calibration curve for the method was generated in a wide range of 10 mg/100 mL to 160 mg/100 mL, allowing both limits to be identified.