TOF and Q-TOF liquid chromatography/mass spectrometry technologies are improving rapidly and showing impressive gains in performance. Agilent's TOF and Q-TOF instruments deliver excellent performance in all dimensions simultaneously, including mass accuracy, resolution, dynamic range, sensitivity, and spectral acquisition speed. Agilent True High-Definition TOF technology achieves exceptional mass accuracy, high resolution, great sensitivity, wide dynamic range, and fast data acquisition rates without compromises.
This document describes Agilent Technologies' True High-Definition (Hi-Def) Time-of-Flight (TOF) and Quadruple Time-of-Flight (Q-TOF) liquid chromatography/mass spectrometry technologies. The text explains how these systems achieve exceptional performance in mass accuracy, resolution, dynamic range, sensitivity, and spectral acquisition speed without the compromises found in other TOF or orbitrap systems.
The document details specific innovations such as dual-stage ion mirrors, proprietary INVAR flight tubes for thermal stability, and 4GHz ADC electronics. It highlights that this technology is available on the Agilent 6200 Series Accurate-Mass TOF LC/MS and 6500 Series Accurate-Mass Q-TOF LC/MS systems.
| Mass Accuracy (MS) | <1 ppm |
|---|---|
| Mass Accuracy (MS/MS) | <3 ppm |
| Mass Resolving Power | 20,000 |
| Data Acquisition Rate (MS) | 40 spectra per second |
| Data Acquisition Rate (MS/MS) | 10 spectra per second |
| Dynamic Range | 5 orders of magnitude |
| Mass Range | 25 to 20,000 Da |
The technology is available on the Agilent 6200 Series Accurate-Mass TOF LC/MS and 6500 Series Accurate-Mass Q-TOF LC/MS systems.
The 4GHz ADC electronics enable a high sampling rate of 32 Gbit/sec.