The Application Note describes the analysis of paracetamol and aspirin to demonstrate that typical accep- tance criteria for a USP method can be fulfilled.
The document describes an analytical method for determining paracetamol and aspirin in pain relievers. It utilizes the Agilent 1220 Infinity LC System, which consists of an isocratic pump, a manual injector, and a variable wavelength detector (VWD). The system configuration includes an Agilent ZORBAX Eclipse Plus C18 column and specific mobile phase conditions derived from USP methods.
The system has an extraordinary pressure range up to 600 bar.
The isocratic pump has a flow range of 0.2 to 10 mL/min.
The variable wavelength detector features a wavelength range from 190 nm to 600 nm.