This application note demonstrates the applicability of SFC for typical polymer additives using the Agilent 1260 Infinity Analytical SFC System in combination with an Agilent 6130 Single Quadrupole LC/MS System.
This document describes an analytical method using Supercritical Fluid Chromatography (SFC) coupled with Mass Spectrometry (MS) to detect polymer additives that may migrate from food packaging materials. The method is validated against EU Directive 2002/72/EC requirements for testing materials in contact with food.
The application note details the analysis of a standard mixture containing six typical polymer additives, including plasticizers, antioxidants, and light stabilizers. It also demonstrates the system's capability to screen unknown solutes extracted from a polymer sample intended for food packaging, successfully identifying compounds that other techniques like GC/MS or HPLC/UV failed to detect.
| Column | 2x Agilent ZORBAX RX-SIL (4.6 x 250 mm, 5 µm) |
|---|
The analysis uses an Agilent 1260 Infinity Analytical SFC System coupled to an Agilent 6130 Single Quadrupole LC/MS System.
The method is useful for screening a wide range of polymer additives and oligomers typically in a molecular weight range from 200-1500.