Industrial

This document describes an LC/MS method that can simultaneously detect CYP3A4, CYP2D6 and CYP2C9 metabolites with high sensitivity

This document describes a method for pesticide residue analysis in agricultural products. By using a 0.15 mm small diameter capillary GC column, 200 pesticide residues can be separated and quantified quickly and successfully. This method improves instrument productivity and reduces detection limits while improving signal to noise ratios.

This document describes the quantitation of a dinitro flavonoid (DNF) in rat plasma using the Varian 1200L LC/MS/MS system. Flavonoids are compounds that make up the pigments in fruits, vegetables, and herbs. There have been reports of flavonoids having multiple beneficial therapeutic effects for a large number of serious illnesses, such as rheumatoid arthritis, cancer, cataracts, anxiety, and depression. The objective of this work was to carry out a pharmacokinetic evaluation to determine a profile with the formulation being tested at increasing doses where there is pharmacological effect. A Varian 1200L LC/MS/MS system was used for the quantitation of plasma levels of a novel dinitro-substituted flavone (DNF) in samples from a pharmacokinetic study following oral administration of the drug. Flavone was used as the internal standard. Structures are shown in Figure 1.

This document describes two ionization methods, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), for molecular weight determination using a liquid chromatography/mass spectrometry (LC/MS) system. ESI is suitable for ionization of a wide variety of compounds, while APCI is used for compounds that do not ionize well with ESI. The document also provides the molecular formulas and molecular weights of two compounds.

This document demonstrates the femtogram sensitivity of the antipsychotic drugs Raclopride and Ritanserin using the Varian 1200L LC/MS/MS in selected reaction monitoring mode (SRM). Ritanserin is a serotonin-2 antagonist drug shown to be effective in the treatment of anxiety and depression, while Raclopride acts as a dopamine D2 receptor antagonist. The document also provides information on the instrumentation and sample preparation methods used in the study.

The LP064V1 is a 6.4 inch VGA resolution TFT LCD display produced by LG.Philips LCD company.

This document presents a detailed hydrocarbon analysis of petroleum naphthas using the ASTM D 5134 method. The method utilizes Varian's GC instrumentation and CP-Sil PONA CB™ column to determine hydrocarbon components eluting after n-nonane. This method is important for quality control, controlling refinery processes, and evaluating raw materials.

This application note describes work to determine if concurrent heating could be used to significantly reduce the analysis time and improve sample throughput in the PIONA+ mode.

This article describes the application of Varian's 320-MS triple quadrupole LC/MS/MS system in the direct aqueous injection and automated on-line solid phase extraction (SPE) analysis of phenoxy herbicides in drinking water. Phenoxy herbicides are a class of chemicals related to the growth hormone indoleacetic acid. Contact with broad-leaf plants induces rapid, uncontrolled growth, killing the affected plants. Phenoxy herbicides are widely used to selectively destroy broad-leaved weeds amongst wheat or corn crops. The best-known phenoxy herbicides are 2,4-dichlorophenoxy-acetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). 2,4,5-T itself is only moderately toxic, with an oral LD50 of 389 mg/kg. However, the manufacturing process for 2,4,5-T contaminates this chemical with trace amounts of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is reported to be extremely toxic to humans. 2,4-D has not been reported as being contaminated with TCDD, however it is one of the most widely used herbicides in the world and is a regulated drinking water contaminant in the United States and other countries.

The LP2982 is a 50mA, fixed-output voltage regulator designed to provide ultra low dropout and lower noise in battery powered applications.

This application note describes how to use the SelecTemp™ and SelecFlow™ features on the Varian 325-MS triple quadrupole mass spectrometer to determine pesticides in a QuEChERS matrix.

This application note examines some analytical figures of merit for selected elements in a variety of lamp combinations using flame atomic absorption spectrometry. The same elements are determined in a number of steel reference materials and samples, with similar results. Evidence is presented that well-designed multi-element lamps can give analytical performance at least as good as that of single-element lamps.

This application note describes the analysis of very low levels (sub ppm) of 1,2-dichloroethane in which a special sample concentratior was used in conjunction with the Varian CP-4900 DMD Micro-GC with differential mobility detector.

This document describes a method for analyzing vulcanized rubber formulations using the Varian 500-MS ion trap mass spectrometer and confirming expected structures using Varian TurboDDS™ and ACD/MS Manager software.