This document introduces medical product innovations since 1928, primarily the Emerson CoughAssist™ Mechanical In-Exsufflator (MI-E). The product assists patients in clearing retained bronchopulmonary secretions by gradually applying positive pressure to the airway, then rapidly shifting to negative pressure. It has automatic and manual models, which can be used with a facemask, mouthpiece, or endotracheal/tracheostomy tube.