This document highlights the differences between the ST10F269Zx and ST10F272Z2 devices, which are members of the STMicroelectronics ST10 family of 16-bit single-chip CMOS microcontrollers. It describes the modified and new functionalities and registers of the ST10F272Z2, and provides advice on handling the differences that may impact the replacement of the ST10F269Zx with the ST10F272Z2. It is intended for hardware or software designers adapting existing applications based on the ST10F269Zx to the ST10F272Z2.