Agilent Multimode Source Technical Overview Application Note

This document introduces the setting, use and maintenance of the Agilent multimode source.

Brand: Agilent
Document type: Application Note
Language: English
Pages: 8
File format: PDF
File size: 474 KB
Published: 05 July, 2012
Updated: 30 September, 2023
MD5 checksum: 93BD5A700C49BBDC9B0946DA008B66BF
PDF: Agilent Multimode Source Technical Overview Application Note PDF

About this manual

This document provides a technical overview of the Agilent multimode source, an ionization device capable of simultaneous electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). It explains how to determine the optimal operating mode based on analyte characteristics and sample diversity. The guide details the benefits of using this versatile source for high-throughput applications and walk-up scenarios.

What's inside

Technical Overview
Optimizing the Agilent Multimode Source
High Sample Diversity and High Throughput Applications
Walkup Applications
High Solvent-Flow Applications
Operating Modes (ESI, APCI, Mixed)
Solvent Flow Rates and Organic Solvents
Use of Modifiers
Column Selection (2.1-mm vs 3.0-mm)

Specifications

Flow rate range without splitting	up to 2 mL/min
Very low solvent-flow limit	less than 25 pL/min
Optimized solvent flow rate range	400 and 1000 L/min
Maximum aqueous flow rate without splitting	2000 pL/min
Emitter power rating	270 W

Frequently asked questions

Which organic solvent is preferred for APCI mode?

Methanol is strongly preferred for the organic solvent in APCI mode.

Can the multimode source operate in ESI-only and APCI-only modes?

Yes, it can operate in ESI-only and APCI-only modes with sensitivity similar to dedicated sources.

Download PDF (474 KB)