Varian's 320-MS triple quadrupole system meets the quality guidelines for qualifier assessment and ion ratio stability set by the European Union for the detection and analysis of toxic compounds.
The document evaluates the applicability of European Union criteria for LC/MS/MS on the Varian 320-MS triple quadrupole system. It focuses on the detection and analysis of carcinogenic mycotoxins, specifically Aflatoxins B1 and B2, to verify compliance with quality guidelines set by the EU Council Directive.
Testing was conducted using spiked samples in buffer over four orders of magnitude (0.35 ppb to 350 ppb) and in a complex matrix (wheat beer). The results demonstrate that the system provides excellent ion ratio stability across a wide calibration range, with observed tolerances far below the maximum permitted levels set by the European Union.
The default tolerance level is 20%.
The average observed tolerance was 7.15%.