This document describes the innovative features of Agilent 400-DS Dissolution Apparatus 7, including automation and integration for small-volume dissolution testing. It is suitable for testing combinatorial drug products such as drug eluting stents, extractables and leachables, and other extended-release pharmaceutical products.
The Agilent 400-DS Dissolution Apparatus 7 is a specialized instrument designed for the small-volume dissolution testing of combinatorial drug products, such as drug-eluting stents (DES), extractables, leachables, and other extended-release pharmaceuticals. It features bathless heating with integrated temperature probes to ensure accurate results without requiring a water bath.
The apparatus is capable of simultaneously testing up to 12 samples along with a control or standard. Key features include magnetically-coupled agitators for reciprocating motion, an integrated autosampler with fluidics capabilities for automated media replacement using up to four different media types, and sampling ports at the base of the dissolution cells for reliable liquid handling.
It is specially designed for small-volume dissolution testing of combinatorial drug products such as drug eluting stents, extractables and leachables, and other extended-release pharmaceutical products.
The apparatus can handle media volumes as low as 3 mL.
The dissolution apparatus can simultaneously test up to 12 samples and a control or standard.