Agilent Manuals

This article describes the sensitive impurity detection of drug intermediates produced by Agilent Technologies, Inc. High purity standards are required for drug intermediates in the production of flurazepam, enalapril, and flunarizine. The Agilent LC/MSD Ion Trap was used to obtain LC/MS and MS/MS data for each intermediate, providing sufficient information to propose structures for the corresponding impurities.

The Varian 500-MS Ion Trap Mass Spectrometer can be used for the analysis of isocyanate derivatives. This method separates and identifies four isocyanate derivatives at low concentrations, with a short analysis time.

This application note describes a method for characterizing the multi-component, polymeric emulsifier Ethomeen T/20H using TurboDDS™ on the Varian 500-MS Ion Trap LC/MS

The document evaluates the usefulness and performance of the Varian 1200L LC/MS/MS for the analysis of Cyclosporin A. The system includes automated on-line extraction and is controlled and fully automated through the Varian MS Workstation software. The Multi Reaction Monitoring (MRM) capability is used to demonstrate the sensitivity and robustness of the LC/MS/MS system.

This publication describes the method of controlling Agilent 1260 Infinity LC Systems using Waters Empower chromatography data software through emulation mode. The software supports the evaluation of two-dimensional, three-dimensional, and spectral raw data acquired by Agilent 1260 Infinity UV detectors, except the Agilent 1260 Infinity DAD. It also provides support for maintenance and diagnostics through Agilent Lab Monitor and Diagnostic software.

This is an application note that introduces the application of mass spectrometry with evaporative light scattering detection

This application note introduces a new method for studying the dynamics of biomolecules, based on ultrafast NMR spectroscopy and the performance of Varian cold probes.

This article describes a method for quantitative measurement of the cardiac glycoside, Digoxin, in human plasma using a Varian 1200L LC/MS/MS system in the negative ion detection mode. This method is capable of detecting Digoxin levels as low as 15 picograms.

This document describes the analysis method for sulfur components in various LPGs. A highly selective pulsed flame photometric detector is used, and a dual-channel configuration is employed for the analysis. This method allows for the analysis of all components of interest in one run.

This application note demonstrates how phospholipids can be identified in a mixture by triple quadrupole mass spectrometry and suspected structures confirmed by generating MS/MS spectra and submitting it to the ACD Labs/MS Manager software.

Analysis of Chloramphenicol in Shrimp by LC/MS/MS

This document describes a method for analyzing vulcanized rubber formulations using the Varian 500-MS ion trap mass spectrometer and confirming expected structures using Varian TurboDDS™ and ACD/MS Manager software.

This application note describes the analysis of very low levels (sub ppm) of 1,2-dichloroethane in which a special sample concentratior was used in conjunction with the Varian CP-4900 DMD Micro-GC with differential mobility detector.

This application note examines some analytical figures of merit for selected elements in a variety of lamp combinations using flame atomic absorption spectrometry. The same elements are determined in a number of steel reference materials and samples, with similar results. Evidence is presented that well-designed multi-element lamps can give analytical performance at least as good as that of single-element lamps.

This application note describes how to use the SelecTemp™ and SelecFlow™ features on the Varian 325-MS triple quadrupole mass spectrometer to determine pesticides in a QuEChERS matrix.