The document introduces a high-throughput biological analysis system that can analyze over 3,500 samples per instrument per shift. It has a flexible format compatible with SBS standard 96 or 384-well plates. The system integrates sample purification, allowing direct sampling from assay plates containing microsomal protein without pre-processing or extraction. It is fully compatible with the Agilent 6410 triple quadrupole mass spectrometer and offers ESI, APCI, and multimode ionization options. The system can detect native molecules, eliminating the need for fluorogenic substrates. The BioTrove RapidFire data analysis software is easy to use and eliminates bottlenecks in data processing. The system comes pre-installed with twelve validated CYP enzyme analysis methods. Custom assay development is also available.
The Agilent 6410 triple quadrupole mass spectrometer combined with BioTrove's RapidFire system provides an integrated solution for high-throughput preparation and analysis of in vitro biological assays in pharmaceutical drug research. This native detection technology allows researchers to obtain mass spectrometry-based data in a fraction of the time needed for traditional LC-MS techniques, specifically for screening Cytochrome P450 (CYP) interactions.
| Sample Throughput | Over 3,500 samples/instrument/shift |
|---|---|
| Plate Format | SBS standard 96 or 384-well plates |
| Sample Processing | On-line clean-up permits direct sampling |
| Ionization Modes | ESI, APCI and multimode |
| Weight | 170 kg (875 lbs) |
| Footprint | 152 x 183 x 76 cm (WxHxD) |
| Electrical Requirements | 115 V, 60 Hz, 15 AMP |
| Warranty | 1-year parts, labor and travel |
The system analyzes over 3,500 samples per instrument per shift.
No, on-line clean-up permits direct sampling from assay plates containing microsomal protein without pre-processing.
The system is compatible with SBS standard 96 or 384-well plates.
The system supports ESI, APCI and multimode ionization.