Varian Intrinsic Dissolution Apparatus is a device for measuring drug dissolution. It can measure the dissolution rate constant of pure drug substances (APIs), which can be used to optimize formulations and predict potential bioavailability issues.
The Agilent Intrinsic Dissolution Apparatus provides a convenient and precise way to measure intrinsic dissolution rates by exposing pure active pharmaceutical ingredient (API) to a constant surface area of dissolution medium. The apparatus is durable, made from stainless steel and hardened steel, and is fully compliant with USP General Information Chapter <1087> Apparent Intrinsic Dissolution.
In the analytical R&D lab, this apparatus helps compare different physicochemical states of the API from various manufacturing processes. It is based on the modified Woods apparatus design, featuring threaded rings to prevent the compacted API from falling out of the die cavity during analysis.
| Exposed Surface Area | 0.5 cm² or 0.125 cm² |
|---|---|
| Operating Temperature | 37 °C |
| Incompatible Models | 7030, 709-DS |
It provides a convenient and precise way to measure intrinsic dissolution rates by exposing pure active pharmaceutical ingredient (API) to a constant surface area of dissolution medium.
The apparatus immerses a fixed amount of material in 37 °C dissolution medium.
The apparatus has a 0.5 cm² exposed surface area for use with part number 42-4100.