Agilent Manuals

A new technique for the analysis of corundum that has undergone heat treatment and beryllium diffusion to resemble one of the most valuable colored stones: vivid orange-yellow gems known as padparadscha is developed in this study. The technique is based on laser-induced breakdown spectroscopy (LIBS), and chemical analysis with inductively coupled plasma-mass spectrometry (ICP-MS) is used to verify the LIBS data. The method can be used to distinguish natural and treated gems, especially in the case of unknown treatments. This study shows that the method can be used to determine the authenticity of gems.

Inductively coupled plasma mass spectrometry can be used as a powerful screening tool for the presence of toxic elements and chemicals in the environment. It has the ability to quickly and quantitatively screen many types of samples for toxic metals at ultratrace levels. When hyphenated with gas or liquid chromatography systems, it can also distinguish toxic from nontoxic species of most elements including radioactive forms. Using retention time locking and compound independent calibration, gas chromatography inductively coupled plasma mass spectrometry (GC-ICP-MS) has the potential to accurately identify and quantify a wide range of volatile toxic organic compounds without the necessity of possessing or analyzing standards for each target analyte. As such, when used in conjunction with other analytical techniques, inductively coupled plasma mass spectrometry can be a valuable tool in the arsenal against environmental terrorism.

This application note demonstrates the suitability of a newly developed, high sensitivity reaction cell inductively coupled plasma mass spectrometer (ICP-MS) for the deter- mination of inorganic impurities in semiconductor-grade tetramethyl ammonium hydroxide (TMAH).

This application note demonstrates the suitability of a newly developed, high sensitivity reaction cell inductively coupled plasma mass spectrometer (ICP-MS) for the determination of inorganic impurities in semiconductor grade sulfuric acid. The Agilent 7500cs ICP-MS, featuring a high sensitivity version of the Octopole Reaction System (ORS), was used to analyze sulfuric acid for all the metals required by the semiconductor industry. The enhanced ORS eliminates all plasma and matrix based polyatomics that interfere with the measurement of elements such as K, Ca, Ti, Cr, Fe, Co, Ni, Cu, and Zn while offering excellent ion transmission and sensitivity. Furthermore, all analytes can be measured at high plasma power to promote complete decomposition of the sulfuric acid in the plasma. This leads to high signal stability and a reduced frequency of routine maintenance. Sample preparation is a simple 10x dilution followed by direct analysis thereby significantly reducing the potential for the sample contamination frequently encountered with evaporative matrix elimination techniques.

The Agilent 7500c Inductively Coupled Plasma Mass Spectrometer (ICP-MS) was used for the fast, routine, and reliable analysis of 23 trace elements in urine.

This study describes the development of a robust high-throughput analytical method for the determination of 18 elements (15 trace elements and 3 electrolytes) in blood and serum samples using an Agilent Technologies 7500ce collision/reaction cell ICP-MS system. The only sample preparation necessary was dilution using an alkaline diluent containing ammonia, EDTA Triton X-100, and butan-1-ol. Instrument calibration was performed using external calibration with internal standardization. The performance of the method exceeded a previously-used magnetic sector HR-ICP-MS method by at least a factor of three in terms of sample throughput and matched the precision and detection limits of that method.

Laser Ablation (LA)-ICP-MS for Production Control of Nickel Alloys

This document introduces a GC/MS with ECD method for determination of isosorbide-5-mononitrate in human plasma.

This document introduces the optimized sources for electron ionization (EI) and chemical ionization (CI) of Agilent 5973x gas chromatograph/mass selective detectors (GC/MSDs). It also demonstrates how to acquire high-quality EI spectra with the CI source without changing the sources. The experimental results show that using the CI source can obtain comparable major and minor peaks to the EI source.

The document introduces a method for determining residual solvents in pharmaceuticals using Agilent G1888 Network Headspace Sampler.

The use of a highly inert capillary column can facilitate the quantitation of low levels of very active compounds. The use of the highly inert HP-5MSi column in conjunction with the Agilent 6890/5973 inert gas chromatograph/mass spectrometer (GC/MS) system allows the measurement of pesticides and environmental contaminants at low levels while maintaining response linearity over a wide concentration range.

A USGS analytical method using gas chromatography/mass selective detector (GC/MSD) was modified and used to identify the source of pesticides and to calculate the pesticide load in river water during storm seasons. The method was validated to cover 12 organophosphate pesticides and 5 pyrithroids. The limits of quantitation for these target compounds are 10–500 ppt using a GC/MSD selected ion monitoring (SIM) method.

This article introduces the new features of Agilent Technologies, Inc.'s 5973N inert mass spectrometer detector and ChemStation software, which allows for operation of the ion source at higher temperatures, providing improvements in analysis. It also provides advice and examples on how to explore the utility of ion source temperature.

This application note describes a method for the analysis of volatile organic compounds (VOCs) in water samples according to US Environmental Protection Agency (USEPA) method 8260B.