Hadamard spectroscopy is a technique based on the selective excitation of a predetermined set of frequencies, which replaces the traditional non-selective RF pulse(s) and the evolution delay for spin excitation and frequency encoding. The VnmrJ 3.1 software can easily set up Hadamard experiments to increase the efficiency of small molecule experiments.
The document describes a method called Hadamard spectroscopy, which reduces data acquisition time in multi-dimensional NMR by exciting and sampling only frequencies of interest instead of using stepwise increments. This approach can significantly speed up experiments like COSY, NOESY, and HSQC.
It details the implementation of this technique within the VamrJ 3.1 software package from Agilent Technologies. The text explains how to set up these fast methods manually or through automation in a Study Queue, noting that while generation requires knowing resonance positions, the resulting data is comparable to traditional experiments.
| Acquisition time for 2D experiment | less than 1 minute |
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It significantly reduces data acquisition time by exciting and sampling only frequencies of interest.
The VamrJ 3.1 software from Agilent Technologies enables easy setup of these fast methods.