Agilent 1260 Infinity HPLC-Chip/MS System Product Leaflet

About this manual

The Agilent 1260 Infinity HPLC-Chip/MS system utilizes revolutionary second-generation microfluidic chip technology specifically designed for nanospray LC/MS. Key components include Agilent 1260 Infinity Capillary and Nanoflow Pumps, a High Performance Micro Autosampler with Thermostat, and a Chip Cube MS interface compatible with Agilent 6000 Series Mass Spectrometers. The system is controlled via Agilent ChemStation or MassHunter software.

What's inside

• Biomarker discovery and validation
• Phosphopeptide analysis
• Intact monoclonal antibody characterization
• Drug metabolism and pharmacokinetic studies
• Small molecule analysis
• Chip technology features
• Data analysis software

Frequently asked questions

What is the minimum blood sample volume required for drug metabolism and pharmacokinetic studies using the Agilent 1260 Infinity HPLC-Chip/MS system?

The system can quantify compounds of interest from complex biological matrices using less than 10 uL of blood sample.

How much less sample does the HPLC-Chip/Q-TOF or TOF MS system require compared to conventional HPLC methods?

The system requires almost 1000 times less sample than conventional HPLC methods.

What is the typical mass accuracy achieved when analyzing MAb tryptic digest with HPLC-Chip and quadrupole time-of-flight MS?

This combination usually yields high mass accuracy, typically below 5 ppm.