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In this Technical Note, we describe the hardware and software involved in PSO Europe Valve Solutions for increasing productivity by adding functionality to the Agilent 1100 Valve Series. The solution offers new automation capabilities, through the use of Agilent 1100 Valves and/or Rheodyne valves in combination with Agilent ChemStation and the PSO Valve Add-on macro. This provides an evolution for flexibility and productivity, with programmable automatic preparation and sequence controlled valve switching.

This document introduces the design method of 1100 LC/MSD system, including cool non-heated capillary, HPLC flow rate conditions set independently of the ion optics lens in the high vacuum region of the mass spectrometer.

This note explores what parameters settings to use to obtain the best data and avoid signal loss when the LC/MSD is used in positive/negative switching mode.

The Agilent 1100 Series LC/MSD quadrupole mass spectrometer features an automatic tuning program (Autotune) that performs this function without operator interaction. One of the essential functions within Autotune is gain checking and gain calibration. This note provides an overview of LC/MSD tuning and the Autotune function, and a more detailed look at gain calibration and adjustment within Autotune.

This technical note introduces the advantages of using an orthogonal nebulizer orientation in electrospray for quantitative analysis of complex samples in quadrupole and ion trap mass spectrometers.

This document introduces the Gain Normalization function implemented in the ChemStation G1701EA (E.02.xx) software. It includes new Gain selection items and expanded Gain Normalization to chemical ionization modes. The advantages of Gain Normalization are described, and how to specify Gain settings in methods are introduced.

When using mass spectrometry to analyze samples containing unknowns, it is often necessary to derive elemental compositions (molecular formulas) for the unknowns based on the mass spectral data. For lower-mass compounds, accurate-mass measurements may be sufficient to produce a single, conclusive molecular formula or a small number of possible formulas. With increasing mass, however, the number of possible formulas increases dramatically. Additional constraints must be applied to reduce the list of candidate formulas to a manageable number. Agilent MassHunter Workstation software includes proprietary molecular formula generation (MFG) software. This software takes full advantage of the mass accuracy of the data, and then uses additional mass spectral information to logically narrow the list of possible formulas. It reduces ambiguity and delivers a list of candidate molecular formulas with scores based on the relative probability that each formula is the correct one. This significantly reduces data interpretation time and increases the value of accurate-mass analysis.

The new Triple-Axis detector (TAD) uses a unique geometry and employs an improved electron multiplier design that will provide the user with several practical advantages. At a given operating gain, the new detector provides higher signal intensity by collecting more ions emerging from the quadrupole. Although signal is enhanced, neutral noise is substantially reduced through the off-axis design. Detector lifetime is also increased under proper operation.

This document introduces the ion optics design innovations that contribute to the outstanding sensitivity of the Agilent Technologies 6400 Series Triple Quadrupole and 6500 Series Quadrupole Time-of-Flight LC/MS systems.

Agilent's Multiple Affinity Removal System is a polyclonal antibody-based system that rapidly depletes multiple high-abundance proteins in serum, plasma or CSF. The system was launched in August 2003 and remains the leading technology in this market.

GC-ICP-MS technology helps solve the problem of low detection limits for siloxanes in biogas usage. It has low detection limits and high sensitivity. The technology allows for accurate quantification of any volatile Si containing compound based on the response of a single standard compound.

The Agilent 1200 Series RRLC system is designed for conventional LC with long columns of large internal diameter as well as for ultra-fast or rapid resolution LC with narrow bore column of about 2.1 mm id. Using a 600 bar, 2-position/6-port valve provides for switching between optimized conditions for both types of analysis.

This document introduces the performance characteristics of the Agilent 1120 Compact LC, including high precision time and area, precise gradient formation and excellent signal-to-noise ratio

This document introduces GCRMA usage.

This document introduces RMA (Robust Multi-array Analysis) method, which is used to normalize and summarize probe-level intensity measurements from Affymetrix Gene Chips ®.