This document introduces the principle, technology application and other information of TOF MS
This document provides a technical overview of orthogonal acceleration time-of-flight (oa-TOF) mass spectrometry. It covers the basic theory of operation for instruments interfaced with atmospheric pressure ionization sources, such as electrospray and MALDI.
The text details the flight time equations used to determine mass-to-charge ratios based on ion velocity and distance. It also explains the measurement cycle, including the role of ion mirrors in improving resolution and the process of mass calibration using known standards.
A high-voltage pulse is applied to the back plate of the ion pulser to accelerate ions through the stack of plates toward the detector.
The flight tube is about one meter in length.
The second ion guide is driven by an RF power amplifier operated at 5 MHz.