The Agilent 5975 inert Gas Chromatograph/Mass Spectrometer is suitable for pharmaceutical applications and offers efficient analysis of residual solvents.
The Agilent 5975 inert Gas Chromatograph/Mass Spectrometer is part of Agilent's pharmaceutical industry solution, designed for routine quality control analysis of manufactured drugs, packaging materials, and raw materials. It can be combined with the Agilent 7683 liquid autosampler and Agilent G1888 headspace samplers to analyze active compounds that would otherwise be difficult to analyze. The system is particularly useful for investigating out-of-specification results by identifying and characterizing impurities in manufactured drug compounds.
| Maximum mass | 1060 Da |
|---|---|
| Scan rate (electronic) | Up to 10,000 amu/s |
| Pumping system | 70 L/s or 262 L/s turbo-molecular pump with 2.5 m³/h mechanical pump |
| El scan sensitivity | 100:1 S/N for 1 pg OFN scanning from 50-300 amu at nominal m/z 272 ion |
| PCI scan sensitivity | 12:1 S/N for 10-0-pg BZP scanning from 80-230 amu at nominal m/z 183 ion |
| NCI scan sensitivity | 300:1 S/N for 100-fg OFN |
The main application is the analysis of residual solvents in drug substances to ensure that limits defined by regulatory authorities are not exceeded.
MSDs offer higher selectivity and sensitivity, comply with regulations, are available at a lower price, and provide time-savings by acquiring quantitation data as well as confirmation information.
The MSD Security ChemStation software addresses all aspects of data security, integrity, and traceability mandated by FDA's 21 CFR part 11 regulations.
The maximum mass detectable by the 5975 inert MSD is 1060 Da.