The Agilent 1100 series is the industry standard for HPLC analysis and has the largest customer base worldwide (over 35,000 systems sold) for various applications, from cutting-edge proteomic research to routine quality control. The 1100 series offers a wide range of pumps, injection systems, and high-performance detectors, catering to different sample scales, from attomoles to gram-scale sample purification. It provides maximum productivity and unmatched reliability, with automated predictive validation and maintenance tools to prevent unexpected downtime. The series also offers fully integrated MS and MSn systems from a single supplier, facilitating access to the power of SM detection, whether coupled with CPL or EC. The specialized software includes modules of increasing complexity for data storage and security, method validation, high-throughput quantification, and specialized modules, such as size exclusion chromatography or sample purification.