The document is a user manual for a product of a certain brand. It introduces the basic functions and usage methods of the product, as well as the features and advantages of the product.
CombiZorb MP-Isocyanate is a solid-supported reagent designed to scavenge primary and secondary amines, anilines, hydrazines, and other nucleophiles. It consists of spherical, macroporous polystyrene/DVB particles with a density of 0.6 g/ml and a particle size range of 30-100 µm.
The material is compatible with common solvents such as THF, toluene, DMF, i-PrOH, and methanol (up to 50-60% loading capacity). It selectively removes amines in the presence of alcohols due to their higher reactivity towards isocyanates. Typical usage involves adding 2-4 equivalents relative to nucleophiles at ambient temperature with gentle agitation for 2-5 hours.
| Particle Type | Spherical, macroporous polystyrene/DVB particle |
|---|---|
| Density | 0.6 g/ml |
| Particle Size | 30-100 µm |
| Swelling in THF or CH2Cl2 | 20-30 % |
| Capacity (benzylamine uptake) | 0.9-1.2 mmol/g |
It scavenges primary and secondary amines, anilines, hydrazines, and other nucleophiles.
Yes, it is compatible with methanol and can use up to 50-60% loading capacity in it.
Use 2-4 equivalents relative to nucleophiles at ambient temperature with shaking or gentle agitation for 2-5 hours.