Agilent ChIP-on-chip Genome-Wide Location Analysis Brochure

Agilent's ChIP-on-chip (chromatin immunoprecipitation-on-chip) is a powerful technology driving the next generation of microarray applications. This emerging platform goes beyond gene expression to explore gene regulation activity and allows determination of the precise location on the DNA sequence where a protein is bound. It pairs chromatin immunoprecipitation (ChIP) and Agilent's 60-mer DNA microarrays to provide comprehensive and genome-wide insight into transcriptional regulation and epigenomic events. ChIP-on-chip enhances the understanding of vital processes like cell proliferation, cell fate determination, oncogenesis, inflammation, apoptosis, and gene silencing. Transcription is a complex process that requires multiple interactions and orchestrated binding of numerous components. Thus, traditional gene expression analyses provide only partial glimpses into gene regulation, whereas ChIP-on-chip reveals a high-resolution map of transcriptional activities, including activation and repression. By partnering our unparalleled microarray expertise with exclusively patented technology from the Whitehead Institute, Agilent enables you to obtain insightful and robust profiles of DNA-protein binding and promoter occupancy across entire genomes.

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