Agilent 1200 Infinity Series High Dynamic Range Diode Array Detector Solution gives you a linear UV-range more than 30 times wider than before, you can detect and quantify all components in your sample in a single run.
The Agilent 1200 Infinity Series High Dynamic Range Diode Array Detector (DAD) solution expands UV-detection capabilities by combining signals from two diode array detectors fitted with different path length flow cells. One detector uses a 3.7 mm path length for high concentrations, while the other uses a 60 mm path length for low concentrations. Specially developed algorithms correct for retention time differences to compute signals that expand the linear dynamic range by a factor of 30 compared to earlier generation detectors.
This solution allows users to detect and quantify all components in a sample in a single run, eliminating the need for reanalysis, recalibration, or additional sample preparation steps like dilution. It extends the upper linearity level to typically 6 absorbance units, enabling the injection of 3 times more sample while benefiting from lower detector noise. This provides up to 30 times higher sensitivity for the simultaneous analysis of main compounds and impurities, particularly useful in pharmaceutical and chemical industries.
| Linear UV-range expansion factor | 30 times wider than earlier generation |
|---|---|
| Upper linearity level | typically 6 absorbance units |
| Sample injection increase | 3 times more sample |
| Detector noise reduction | 10 times lower detector noise |
| Sensitivity increase | up to 30 times higher sensitivity |
| Flow cell path lengths | 3.7 mm and 60 mm |
It allows you to detect and quantify all components in your sample in a single run, eliminating the need for reanalysis or sample dilution.
It combines signals from two detectors with different path lengths: a 3.7 mm cell for high concentrations and a 60 mm cell for low concentrations.
The solution extends the upper linearity level to typically 6 absorbance units.
It is ideal for impurity analysis of samples with highly different concentrations of active components, such as fixed-dose combinations in pharmaceutical drugs.