Agilent MassHunter Optimizer is an automated MS method development software from Agilent. It can automatically optimize the acquisition parameters for MRM mode (multiple-reaction monitoring) on a triple quad mass spectrometer instrument for each individual compound analyzed. Specifically, it automates the selection of the best precursor ions, the optimization of the fragmentor voltage for each precursor ion, selection of the best product ions, and optimization of collision energy values for each transition for a list of compounds you specify.