Pall USD3000 Application Note Successful Wetting for Filter Integrity Testing

About this manual

This document outlines optimized wetting procedures for filter integrity testing in volume-restricted systems, specifically addressing the challenges of wetting sterilizing-grade filters with low flush volumes. It discusses the decision between pre-use and post-use testing and the selection of appropriate wetting liquids, such as water or product, to minimize product loss and extractables.

What's inside

• Introduction
• Pre-use or post-use test
• Filter Wetting Liquid
• Optimized Wetting Procedure
• Setup for Low-Wetting Volume Integrity Test
• Step by Step Procedure for Basic Manual Wetting
• Product-Wet Integrity Test
• Challenging Wetting Situations
• Automation of Filter Wetting
• Wetting Function of the Palltronic AquaWIT

Frequently asked questions

What is the minimum downstream flush volume required for water wetting in 10-inch filters?

The procedure allows filter wetting with down to two liters downstream flush volume per 10-inch filter.

What is the minimum recommended pressure level for venting during the manual wetting procedure?

The text does not state a specific numerical pressure value, only that venting occurs when a certain pressure level is reached.