To provide reference for the management of package inserts in medical institution. 30 groups of oral drug package inserts with same components from different manufacturers were compared in central pharmacy of our hospital. There are differences in indication，contraindication，pregnant and lactation women medication，children medi- cation，elderly medication in 30 groups of oral drug package inserts with same components from different manufacturers in central pharmacy of our hospital. It may constitute a certain risk to medical institution's medication behavior. It is recommended that medical institutions should manage the information of package inserts used, including the differences between package inserts with same components from different manufacturers to avoid the medication risk caused by this.